The short answer is yes, it can be. If your daughter has the wonderfully remarkable abilities of a gifted student and is an avid reader to boot - she may not always find it easy to speak to her middle school classmates who may not share her love of reading or her abilities.
Ideally, there would be other gifted children or avid readers in her school and you may want to look around a bit to see if there are. If not in school, then it would be the next best thing to find her some reading friends outside of school. Check out a 'hoagies' website easily found on google for advice and connections with the gifted child community.

Good luck.

It's the bane of the gifted and culturally aware kids. My son competes in sport with a whole group of kids, and the one girl who's very bright (and homeschooled) and he could make references about just about anything that the rest of the teens would stand there slack jawed.

Encourage her to have some chronologically age-appropriate friends who can talk about boys and school and the like, but don't worry if she also craves the company of adults. You'll find quickly which of your friends don't mind her accompanying you, and which ones think of all kids as kids.

Many of our friends consider my son one of their friends too given his ability to carry on a conversation. It's often refreshing for other adults to see that some of the next generation are going to be able to contribute positively to their social security accounts.